Isobutyryl chloride → HCID 86592339, compound

Participants

Reaction Steps

Ethyl(3,5-dichloro-4-[4-amino-3-bromophenoxy]phenyl) propionate (50 mg) was coupled with isobutyryl chloride (30 mg), using the method described in Example 1(h). After purification on column (silica gel, ethyl acetate/petrolium ether, 1:9), 50 mg of ethyl(3,5-dichloro-4-[3-bromo-4-isobutyramidophenoxy]phenyl) propionate was obtained, which was hydrolysed using the method described in Example 1(i). This gave 40 mg of 3,5-dichloro-4-(3-bromo-4-isobutyramidophenoxy)phenylpropionic acid.

Provenance & Evidence