4-Fluorobenzoyl chloride → HCID 86592341, compound

Participants

Reaction Steps

Ethyl(3,5-dichloro-4-[4-amino-3-bromophenoxy]phenyl) propionate (70 mg) was coupled with p-fluorobenzoyl chloride (35 mg), using the method described in Example 1(h). After recrystallization (ethyl acetate/petrolium ether), 80 mg of ethyl(3,5-dichloro-4-[3-bromo-4-p-fluorobenzamidophenoxy]phenyl) propionate was obtained, which was hydrolysed using the method described in Example 1(i). This gave 60 mg of 3,5-dichloro-4-(3-bromo-4-p-fluorobenzamidophenoxy)phenylpropionic acid.

Provenance & Evidence