Isobutyryl chloride → HCID 86592343, compound

Participants

Reaction Steps

Ethyl(3,5-dichloro-4-[4-aminophenoxy]phenyl) propionate (80 mg) was coupled with isobutyryl chloride (30 mg), using the method described in Example 1(h). After recrystallization (ethyl acetate/petrolium ether), 80 mg of ethyl(3,5-dichloro-4-[4-isobutyr-amidophenoxy]phenyl) propionate was obtained, which was hydrolysed using the method described in Example 1(i). This gave 50 mg of 3,5-dichloro-4-(4-isobutyramidophenoxy)-phenylpropionic acid, m/z 382.

Provenance & Evidence