Dichloromethane → HCID 86592345, compound

Participants

Reaction Steps

Stannic chloride (50 mg) was added to a stirred mixture of ethyl(3,5-dichloro-4-[4-aminophenoxy]phenyl) cinnamate (0.10 g), triethylamine (40 mg), dichloromethane (5 mL) and 2-chloropropionyl chloride (50 mg). The reaction mixture was heated at reflux for 16 hours. After concentration and partionating of the residue with ethyl acetate and hydrochloric acid (2 N), 80 mg of methyl(3,5-dichloro-4-[4-(2-chloropropionamido)-phenoxy]phenyl) cinnamate was obtained. The intermediate methyl ester was hydrolyzed using the method described in Example 1(i), to give 60 mg of 3,5-dichloro-4-(4-[2-chloropropionamido]phenoxy)phenylcinnamic acid.

Provenance & Evidence