Chloromethyl Methyl Ether → HCID 18448760, compound

HRID 1269580Notes

Reaction equation

HRID 1269580 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[C:16]([CH:17]([CH3:19])[CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=2[CH:20]([CH3:22])[CH3:21])=[CH:6][C:5]=1[O:23][CH3:24])([O-:3])=[O:2].CO[CH2:27][Cl:28]>ClCCl>[CH:17]([C:16]1[CH:15]=[C:14]([CH:13]=[C:12]([CH:20]([CH3:22])[CH3:21])[C:11]=1[O:10][C:7]1[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[C:5]([O:23][CH3:24])[CH:6]=1)[CH2:27][Cl:28])([CH3:19])[CH3:18]

Participants

4

Reactant 2

HCID 7864Chloromethyl Methyl EtherHCID 18448748HCID 18448748, compound

Product 1

HCID 18448760HCID 18448760, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Stannous chloride (0.46 mL) was carefully added under nitrogen gas to a ice-cooled mixture of 2-nitro-5-(2,6-diisopropylphenoxy)anisole (3.8 g), chloromethyl methyl ether (1.8 mL) and dichloromethane (5 mL). After 16 hours, the reaction mixture was concentrated and purified on column (silica gel, ethyl acetate/petroliumether, 97:3), to give 1.4 g of 3,5-diisopropyl-4-(3-methoxy-4-nitrophenoxy)benzylchloride.

Workup

  1. temperaturecooled
  2. concentrationthe reaction mixture was concentrated
  3. custompurified on column (silica gel, ethyl acetate/petroliumether, 97:3)

Sources & evidence

ORD record
ord-74ee3503b4fc4af7af8fd0fa0025e74d
Source dataset
uspto-grants-2007_04
Patent number
US07199265B2

Reaction notes

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