Acetic Acid → HCID 69426186, compound

Participants

Reaction Conditions

Reaction Steps

Sulphuric acid (1.0 mL, 20%) was added to a mixture of diethyl(3,5-diisopropyl-4-[3-methoxy-4-nitrophenoxy]benzyl) malonate (1.4 g), acetic acid (5 mL) and water (5 mL). After heating for 8 hours at 80° C., the reaction mixture was concentrated and ethyl acetate was added to the residue. The organic phase was washed with water and brine. After recrystallization (ethyl acetate/petrolium ether), 1.1 g of 3,5-diisopropyl-4-(3-methoxy-4-nitrophenoxy)phenylpropionic acid was obtained.

Provenance & Evidence