HCID 86592350, compound → HCID 86592349, compound

HRID 1269582Notes

Reaction equation

HRID 1269582 reaction equation
[C:1]([O:5][C:6]1[CH:11]=[C:10]([CH:12]([CH3:14])[CH3:13])[C:9]([O:15][C:16]2[CH:21]=[CH:20][C:19]([N+:22]([O-])=O)=[C:18]([OH:25])[CH:17]=2)=[C:8]([CH:26]([CH3:28])[CH3:27])[C:7]=1[CH3:29])(=[O:4])[CH2:2][CH3:3].[H][H]>[Pd].CO>[C:1]([O:5][C:6]1[CH:11]=[C:10]([CH:12]([CH3:13])[CH3:14])[C:9]([O:15][C:16]2[CH:21]=[CH:20][C:19]([NH2:22])=[C:18]([OH:25])[CH:17]=2)=[C:8]([CH:26]([CH3:28])[CH3:27])[C:7]=1[CH3:29])(=[O:4])[CH2:2][CH3:3]

Participants

5

Reactant 2

HCID 86592350HCID 86592350, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86592349HCID 86592349, compoundYield 100.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Methyl(3,5-diisopropyl-4-[3-hydroxy-4-nitrophenoxy]phenyl) propionate (0.30 g), methanol (10 mL), palladium on carbon (10%) and 1–2 atmospheres of hydrogen gas was stirred at room temperature for 4 hours. After filtration, 0.28 g of methyl(3,5-diisopropyl-4-[4-amino-3-hydroxyphenoxy]phenyl) propionate was obtained.

Workup

  1. filtrationAfter filtration

Sources & evidence

ORD record
ord-72ab84092922494e946a3baae8363490
Source dataset
uspto-grants-2007_04
Patent number
US07199265B2

Reaction notes

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