HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 5-(3-Fluoro-pyridin-4-yl)-1H-pyrimidine-2,4-dione hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 5-(3-Fluoro-pyridin-4-yl)-2,4-dimethoxy-pyrimidine | HCID 58994181 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(3-Fluoro-pyridin-4-yl)-1H-pyrimidine-2,4-dione hydrochloride | HCID 68694276 | 85% |
Reaction Steps
To a solution of 5-(3-Fluoro-pyridin-4-yl)-2,4-dimethoxy-pyrimidine (Prep 66, 725 mg, 3.1 mmol) in MeOH (50 ml) 2N HClaq (20 ml) was added. After refluxing the mixture for 1 hour, the solvents were evaporated and the crude was tritured with hexane then with iPrOH and finally with DCM to give 550 mg of the title compound (85% yield)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727988B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-f57bbcdae829410bbe9f1eaea270f0fb |
| Source note | uspto-grants-2010_06 |