Ammonia → HCID 20287763, compound

HRID 126960Notes

Reaction equation

HRID 126960 reaction equation
[NH3:1].C[O:3][C:4]([C:6]1[C:15]([OH:16])=[CH:14][C:13]2[CH2:12][CH2:11][CH2:10][CH2:9][C:8]=2[CH:7]=1)=O>CO>[OH:16][C:15]1[C:6]([C:4]([NH2:1])=[O:3])=[CH:7][C:8]2[CH2:9][CH2:10][CH2:11][CH2:12][C:13]=2[CH:14]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 265142Methyl 3-hydroxy-5,6,7,8-tetrahydronaphthalene-2-carboxylate

Product 1

HCID 20287763HCID 20287763, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
100 °C

Procedure

To 300 ml of methanol saturated with ammonia gas at 0° C. was added 122 g of 3-hydroxy-5,6,7,8-tetrahydro-2-naphthoic acid methyl ester, and the mixture was maintained in an autoclave at 100° C. for 5 hours. After cooling, the precipitating solid was filtered off, washed with a small amount of methanol, and dried, giving 96 g of a pale yellow crystal having the following physical properties.

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitating solid was filtered off
  3. washwashed with a small amount of methanol
  4. customdried

Sources & evidence

ORD record
ord-ab1882b4e4274d4c9f0e8aea1f5f351a
Source dataset
uspto-grants-1981_03
Patent number
US04254056

Reaction notes

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