反应详情

温度

0 °C

To a suspension of 2-(methylthio)-4-[4-(trifluoromethyl)phenyl]pyrimidine (2.24 g, 8.4 mmol) in methanol (85 mL) and water (85 mL) at 0° C. was added oxone™ (15.25 g, 24.8 mmol). The reaction was stirred at 0° C. for 1 h and then at room temperature for 18 h. The reaction mixture was diluted with water (200 mL) and extracted with chloroform (2×250 mL). The organic solution was dried (Na2SO4) filtered and evaporated to afford the title compound as a white solid (2.235 g).

1. waitat room temperature for 18 h
2. extractionextracted with chloroform (2×250 mL)
3. dry with materialThe organic solution was dried (Na2SO4)
4. filtrationfiltered
5. customevaporated