反应详情

To a mixture of 2,6-dichloropyrazine (0.5 g, 3.36 mmol), sodium carbonate (0.925 g, 8.73 mmol) and 4-trifluoromethylphenylboronic acid (0.638 g, 3.36 mmol) in dimethoxyethane (15 mL) and water (7.5 mL) under nitrogen was added tetrakis(triphenylphosphine) palladium (0) (0.078 g). The resulting mixture was heated at reflux for 5 h under nitrogen, before stirring at room temperature overnight. The reaction was diluted with water (50 mL) and extracted with chloroform (2×75 mL). The organic solution was dried (MgSO4) and the solvents removed in vacuo. Purification by Biotage™ chromatography (Silica, 90 g) 10:1–6:1 cyclohexane:EtOAc afforded the title compound as a white solid (0.317 g).

1. temperatureThe resulting mixture was heated
2. temperatureat reflux for 5 h under nitrogen
3. extractionextracted with chloroform (2×75 mL)
4. dry with materialThe organic solution was dried (MgSO4)
5. customthe solvents removed in vacuo
6. customPurification by Biotage™ chromatography (Silica, 90 g) 10:1–6:1 cyclohexane