反应详情

To a flask containing 2-chloro-6-(4-methylphenyl)pyrazine (2.5 g, 12.3 mmol), was added phosphorus tribromide (20 mL) and the mixture heated at reflux for 6 h under nitrogen. The reaction mixture was cooled to room temperature prior to pouring carefully into iced water (600 mL). The resulting solution was adjusted to pH 6–7 using aqueous ammonia and extracted with Et2O (2×250 mL). The organic solution was dried (MgSO4) and the solvent removed in vacuo to afford the title compound as a white solid (2.32 g).

1. temperaturethe mixture heated
2. temperatureat reflux for 6 h under nitrogen
3. extractionextracted with Et2O (2×250 mL)
4. dry with materialThe organic solution was dried (MgSO4)
5. customthe solvent removed in vacuo