HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-6-(4-chlorophenyl)-5-methylpyrimidine → Ethyl (4-{[[6-(4-chlorophenyl)-5-methylpyrimidin-4-yl](propyl)amino]methyl}-2-methylphenoxy)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-6-(4-chlorophenyl)-5-methylpyrimidine | HCID 18448404 | — |
| Reactant | Ethyl (2-methyl-4-{[{5-methyl-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}(propyl)amino]methyl}phenoxy)acetate | HCID 58622851 | — |
| Product | Ethyl (4-{[[6-(4-chlorophenyl)-5-methylpyrimidin-4-yl](propyl)amino]methyl}-2-methylphenoxy)acetate | HCID 58622844 | — |
Reaction Steps
Using 4-chloro-6-(4-chlorophenyl)-5-methylpyrimidine (167 mg, 0.7 mmol) and the synthetic procedure described for Intermediate 80. Purification by Biotage™ chromatography (Si, 40 g) eluting 9:1 cyclohexane:EtOAc afforded the title compound as a pale yellow oil (116 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07199239B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-8aa5a3d1f41d43a2bb47998b7e16d313 |
| Source note | uspto-grants-2007_04 |