HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-5-methyl-6-(4-methylphenyl)pyrimidine → Ethyl (2-methyl-4-{[[5-methyl-6-(4-methylphenyl)pyrimidin-4-yl](propyl)amino]methyl}phenoxy)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-5-methyl-6-(4-methylphenyl)pyrimidine | HCID 18448402 | — |
| Reactant | Ethyl (2-methyl-4-{[{5-methyl-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}(propyl)amino]methyl}phenoxy)acetate | HCID 58622851 | — |
| Product | Ethyl (2-methyl-4-{[[5-methyl-6-(4-methylphenyl)pyrimidin-4-yl](propyl)amino]methyl}phenoxy)acetate | HCID 58622853 | — |
Reaction Steps
Using 4-chloro-5-methyl-6-(4-methylphenyl)pyrimidine (153 mg, 0.7 mmol) and the synthetic procedure described for Intermediate 80. Purification by Biotage™ chromatography (Si, 40 g) eluting 9:1 cyclohexane:EtOAc afforded the title compound as a pale yellow oil (80 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07199239B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-c7d56863da994f16b312a797f92d55eb |
| Source note | uspto-grants-2007_04 |