Chlorobenzene → Ethyl 4-[4-(4-trifluoromethylphenoxy)phenoxy]-2-pentenoate

참여 물질

반응 단계

In a reactor, 100 ml of chlorobenzene and 100 ml of water were charged and then, 95.3 g (0.375 mole) of 4-(4-trifluoromethylphenoxy)phenol, 85.4 g (0.412 mole) of ethyl 4-bromo-2-pentenoate, 39.0 g (0.281 mole) of potassium carbonate and 1.1 g (0.00375 mole) of tributylethyl ammonium bromide were added. The mixture was refluxed with stirring for 6 hours to react them, and the water phase was removed and the organic phase was washed with 5% hydrochloric acid and with water and then, chlorobenzene, ethyl 4-bromo-2-pentenoate and low boiling by-products were distilled off at 100° C. under a reduced pressure of 0.02 to 0.05 mmHg to obtain 137.0 g of ethyl 4-[4-(4-trifluoromethylphenoxy)phenoxy]-2-pentenoate. The yield was 96.0%.

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