Phthalic Anhydride → HCID 22934003, compound

HRID 1269724Notes

Reaction equation

HRID 1269724 reaction equation
[C:1]1(=[O:11])[O:6][C:4](=[O:5])[C:3]2=CC=CC=[C:2]12.[NH2:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][N:17]=[CH:16]2>CC(C)=O>[NH:18]1[C:19]2[C:15](=[CH:14][C:13]([NH:12][C:1](=[O:11])[CH2:2][CH2:3][C:4]([OH:6])=[O:5])=[CH:21][CH:20]=2)[CH:16]=[N:17]1

Participants

4

Reactant 2

HCID 6811Phthalic AnhydrideHCID 880121H-Indazol-5-amine

Product 1

HCID 22934003HCID 22934003, compoundYield 102.2%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Phthalic anhydride (827 mg, 8.26 mmol) was added to a solution of 5-aminoindazole (1.0 g, 7.51 mmol) in acetone (60 ml) at room temperature, and the resulting mixture was refluxed for 4 hours. The solid precipitated was collected by filtration and dried under reduced pressure to obtain 4-(1H-indazol-5-ylamino)-4-oxobutanoic acid (1.79 g, 100%).

Workup

  1. temperaturethe resulting mixture was refluxed for 4 hours
  2. customThe solid precipitated
  3. filtrationwas collected by filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-36eebc1f809b40ebbca4d5a277307a6e
Source dataset
uspto-grants-2007_04
Patent number
US07199147B2

Reaction notes

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