Ammonium formate → HCID 22934023, compound

Participants

Reaction Steps

Ammonium formate (716 mg, 11.4 mmol) and 10% palladium carbon (containing 50% water, 100 mg) were added to a solution of the N-(1-benzylazepan-3-yl)-1H-indazole-5-carboxamide (494 mg, 1.42 mmol) obtained in Example 147 in ethanol (28 ml) at room temperature, and the resulting mixture was stirred with heating under reflux for 5 hours. The reaction mixture was filtered to remove the catalyst and the solvent of the filtrate was distilled off under reduced pressure. The resulting residue was purified by a silica gel column chromatography (eluent: ethyl acetate/methanol/aqueous ammonia=10/1/0.1) to obtain N-azepan-3-yl-1H-indazole-5-carboxamide (267 mg, 73%).

Provenance & Evidence