Trifluoroacetic acid → HCID 22933906, compound

Participants

Reaction Steps

Trifluoroacetic acid (6.0 ml) was added to the trans-tert-butyl-4-[(1H-indazol-5-ylcarbonyl)amino]cyclo-hexylcarbamate (420 mg, 1.17 mmol) obtained in Example 158, and the resulting mixture was stirred at room temperature for 1 hour. After the reaction solution was concentrated under reduced pressure, ethanol (10 ml) was added to the concentration residue, followed by washing by repulping. The residue washed was filtered and then dried under reduced pressure to obtain N-(4-aminocyclohexyl)-1H-indazole-5-carboxamide trifluoroacetate (363 mg, 83%).

Provenance & Evidence