Ether hydrochloride → HCID 69433061, compound

Participants

Reaction Steps

To a solution of the trans-3-(1H-indazol-4-yloxy)-cyclohexanamine (163.1 mg, 0.705 mmol) obtained in Example 326 in ethanol (3 ml) was added 1M-hydrochloric acid/diethyl ether (0.776 ml, 0.776 mmol) at room temperature. After 1 hour, the resulting solution was concentrated under reduced pressure, and the resulting oil was crystallized by the addition of acetonitrile, followed by filtration. The precipitate was dried under reduced pressure to obtain trans-3-(1H-indazol-4-yloxy)-cyclohexanamine hydrochloride (166 mg, 88%).

Provenance & Evidence