HCID 58994156, compound → HCID 58994175, compound

HRID 12698Notes

Reaction equation

HRID 12698 reaction equation
C[O:2][CH:3](OC)[CH2:4][CH2:5][N:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][C:13]=2[F:18])[C:9](=[O:19])[NH:8][C:7]1=[O:20]>CO>[F:18][C:13]1[CH:14]=[N:15][CH:16]=[CH:17][C:12]=1[C:10]1[C:9](=[O:19])[NH:8][C:7](=[O:20])[N:6]([CH2:5][CH2:4][CH:3]=[O:2])[CH:11]=1

Participants

3

Reactant 1

HCID 58994156HCID 58994156, compound

Product 1

HCID 58994175HCID 58994175, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-(3,3-Dimethoxy-propyl)-5-(3-fluoro-pyridin-4-yl)-1H-pyrimidine-2,4-dione (Prep 68, 75 mg, 0.24 mmol) was dissolved in MeOH (2 ml) and 1N HClaq (500 μl) was added. The mixture was stirred at room temperature for 16 hours. MeOH was evaporated under vacuum and dioxane was added. After heating the mixture at 60° C. for 6 hours the solvents were evaporated to give the title compound that was used in the next step without further purification (63 mg, quantitative yield).

Workup

  1. addition1N HClaq (500 μl) was added
  2. customMeOH was evaporated under vacuum and dioxane
  3. additionwas added
  4. temperatureAfter heating the mixture at 60° C. for 6 hours the solvents
  5. customwere evaporated

Sources & evidence

ORD record
ord-2987d728ae054e93acdca24ab116c5a0
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Reaction notes

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