Diethyl Ether → Methyl 2-(4-chlorophenyl)-3-methylbutanimidate

HRID 126982ノート

反応式

HRID 126982 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:12]([CH3:14])[CH3:13])[C:9]([NH2:11])=[O:10])=[CH:4][CH:3]=1.F[B-](F)(F)F.[CH3:20][O+](C)C.CCOCC.C(=O)(O)[O-].[Na+]>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH:12]([CH3:14])[CH3:13])[C:9](=[NH:11])[O:10][CH3:20])=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 3283Diethyl EtherHCID 516892Sodium BicarbonateHCID 2735153Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1)HCID 128981762-(4-Chlorophenyl)-3-methylbutanamide

生成物 1

HCID 20571405Methyl 2-(4-chlorophenyl)-3-methylbutanimidate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a mixture of 2.32 g (11 mmol) of 2-(4-chlorophenyl)-3-methylbutyramide in methylene chloride is added, at room temperature, 1.78 g (12 mmol) of trimethyloxonium tetrafluoroborate. After stirring overnight under nitrogen, the resulting solution is poured onto an ice-cold mixture of ether and aqueous sodium bicarbonate. The aqueous layer is discarded, and the ethereal layer is washed with cold water and dried over sodium sulfate. Filtration and concentration in vacuo affords methyl 2-(4-chlorophenyl)-3-methylbutanimidate.

後処理

  1. additionis added, at room temperature
  2. washthe ethereal layer is washed with cold water
  3. dry with materialdried over sodium sulfate
  4. filtrationFiltration and concentration in vacuo

出典と根拠

ORDレコード
ord-d9de5dc4c3764659be7fd3d381ac650b
出典データセット
uspto-grants-1981_03
特許番号
US04254264

反応ノート

読み込み中…