Acetic Acid → HCID 18447172, compound

Participants

Reaction Steps

Triethylamine (0.14 ml, 1.0 mmol) was added to a mixture of the 4-methyl-5-(piperidin-3-yloxy)-1H-indazole (92 mg, 0.40 mmol) obtained in Example 422, acetic acid (24 mg, 0.40 mmol), 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide monohydrochloride (77 mg, 0.40 mmol), 1-hydroxybenzo-triazole (54 mg, 0.40 mmol) and N,N-dimethylformamide (1.5 ml), and the resulting mixture was stirred at room temperature for 19 hours. The mixture was diluted with a mixed solution of ethyl acetate (10 ml)/toluene (10 ml) and washed with water and then a saturated aqueous sodium hydrogencarbonate solution. The mixture washed was dried over potassium carbonate and then concentrated to dryness to obtain 5-[(1-acetylpiperidin-3-yl)oxy]-4-methyl-1H-indazole (84 mg, 76%).

Provenance & Evidence