Ether hydrochloride → HCID 22933635, compound

HRID 1269857Notes

Reaction equation

HRID 1269857 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([O:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[CH2:17][N:18]([CH3:20])[CH3:19])=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[ClH:21].C(OCC)C>C(OCC)C>[ClH:21].[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([O:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[CH2:17][N:18]([CH3:20])[CH3:19])=[CH:7][CH:8]=2)[CH:3]=[N:2]1

Participants

4

Reactant 2

HCID 10953452Ether hydrochlorideHCID 22933636HCID 22933636, compound

Product 1

HCID 22933635HCID 22933635, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1-[2-(1H-indazol-5-yloxy)phenyl]-N,N-dimethylmethanamine was dissolved in diethyl ether (2 ml), and a 1N-hydrochloric acid/diethyl ether solution (0.3 ml) was added dropwise thereto at 0° C. The resulting suspension was concentrated to obtain 1-[2-(1H-indazol-5-yloxy)phenyl]-N,N-dimethylmethanamine monohydrochloride (20 mg).

Workup

  1. customat 0° C
  2. concentrationThe resulting suspension was concentrated

Sources & evidence

ORD record
ord-08b0a6d0421b43b29ce815dfc5a9cec4
Source dataset
uspto-grants-2007_04
Patent number
US07199147B2

Reaction notes

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