Water → 4-methyl-1H-indazole-5-carboxylic acid

HRID 1269865Notes

Reaction equation

HRID 1269865 reaction equation
[OH2:1].S(=O)(=O)(O)[OH:3].[CH3:7][C:8]1[C:16]([C:17]#N)=[CH:15][CH:14]=[C:13]2[C:9]=1[CH:10]=[N:11][NH:12]2>C(O)(=O)C>[CH3:7][C:8]1[C:16]([C:17]([OH:3])=[O:1])=[CH:15][CH:14]=[C:13]2[C:9]=1[CH:10]=[N:11][NH:12]2

Participants

5

Reactant 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 229335304-Methyl-1H-indazole-5-carbonitrile

Product 1

HCID 229337204-methyl-1H-indazole-5-carboxylic acidYield 70.1%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Water (2 ml) and concentrated sulfuric acid (2 ml) were added to a acetic acid suspension (2 ml) of 4-methyl-1H-indazole-5-carbonitrile (399 mg, 2.00 mmol) at room temperature, and then the reaction was carried out for 18 hours under reflux conditions. The reaction mixture was poured onto ice (20 g) and the precipitate was collected by filtration and dried to obtain 4-methyl-1H-indazole-5-carboxylic acid (247 mg, 70.1%).

Workup

  1. additionThe reaction mixture was poured onto ice (20 g)
  2. filtrationthe precipitate was collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-eae69a0582ba44e6bc0df8a5a497e611
Source dataset
uspto-grants-2007_04
Patent number
US07199147B2

Reaction notes

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