Hydrazine → (+/-)-3-(2-Furanyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid

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Reaction Steps

Potassium hydroxide (660 mg) is dissolved in 25 cc of methanol and 1.66 g of 4-(2-furanyl)-4-oxo-2-butenoic acid is added. Hydrazine (320 mg) is then added and the solution is refluxed for 2 hours. The methanol is removed and the viscous residue is dissolved in 50 cc of water. The solution is made strongly acid with 20% HCl and a precipitate forms. The solid is filtered quickly to yield 1.2 g of the title compound, melting point 185°-190° C., dec.

Provenance & Evidence