Stannous chloride dihydrate → HCID 178507356, compound

Participants

Reaction Conditions

Reaction Steps

Tin dichloride dihydrate (846 mg, 3.75 mmol) was added to a solution of 3-bromo-5-nitro-1H-indazole (181 mg, 0.748 mmol) in N,N-dimethylformamide (3 ml), and the resulting mixture was stirred at 70° C. for 1.5 hours. After an aqueous sodium hydrogensulfite solution was added thereto to terminate the reaction, ethyl acetate was added to the reaction mixture and the insoluble material was removed by filtration using Celite. The residue was extracted with ethyl acetate/toluene, and the extract solution was washed with a saturated aqueous sodium chloride solution, dried over sodium sulfate, and then distilled under reduced pressure to remove the solvent, whereby 3-bromo-1H-indazol-5-amine (110 mg, 69%) was obtained.

Provenance & Evidence