反应详情

A mixture of 6.6 g of (±)-4,5-dihydro-1-(benzyloxycarbonyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid, 5 ml of isobutylene, 25 ml of ether and 0.25 ml of concentrated sulfuric acid is shaken in a pressure vessel for about 16 hours. The reaction vessel is vented (-10° C.) and the contents are washed with ice cold aqueous sodium hydroxide. The organic fraction is dried over anhydrous magnesium sulfate and concentrated in vacuo to give the title compound.

1. custom(-10° C.)
2. washthe contents are washed with ice cold aqueous sodium hydroxide
3. dry with materialThe organic fraction is dried over anhydrous magnesium sulfate
4. concentrationconcentrated in vacuo