HCID 86737540, compound → (+/-)-4,5-Dihydro-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid, t-butyl ester

HRID 126996Notes

Reaction equation

HRID 126996 reaction equation
C(OC([N:11]1[CH:15]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:14][C:13]([C:23]2[S:24][CH:25]=[CH:26][CH:27]=2)=[N:12]1)=O)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[S:24]1[CH:25]=[CH:26][CH:27]=[C:23]1[C:13]1[CH2:14][CH:15]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[NH:11][N:12]=1

Participants

5

Reactant 2

HCID 86737540HCID 86737540, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86737541(+/-)-4,5-Dihydro-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid, t-butyl ester

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 5.0 g of (±)-4,5-dihydro-1-(benzyloxycarbonyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid, t-butyl ester in 75 ml of ethanol containing 0.5 g of 5% palladium on carbon is hydrogenated at atmospheric pressure until the uptake of hydrogen ceases. The catalyst is removed by filtration through Celite and the filtrate is concentrated in vacuo to yield the title compound.

Workup

  1. customThe catalyst is removed by filtration through Celite
  2. concentrationthe filtrate is concentrated in vacuo

Sources & evidence

ORD record
ord-6f0aff55b685477b9f9edbd03f8521a5
Source dataset
uspto-grants-1981_03
Patent number
US04254267

Reaction notes

Loading…