HCID 69432488, compound → HCID 69436371, compound

Participants

Reaction Steps

To a solution of 1-tetrahydro-2H-pyran-2-yl-5-(tetrahydro-2H-pyran-2-yloxy)-4-vinyl-1H-indazole (1.35 g, 4.11 mmol) in ethyl acetate (40 ml) was added 10%-palladium/carbon (containing 50% water, 50 mg), and the resulting mixture was stirred for 6 hours at ordinary temperature and atmospheric pressure under a hydrogen atmosphere. To the mixture was further added 10%-palladium/carbon (containing 50% water, 670 mg), and stirred for another 1.5 hours. The reaction mixture was filtered by the use of Celite and washed with methanol, and then the filtrate was concentrated under reduced pressure to obtain 4-ethyl-1-tetrahydro-2H-pyran-2-yl-5-(tetrahydro-2H-pyran-2-yloxy)-1H-indazole (1.41 g).

Provenance & Evidence