HCID 69433897, compound → HCID 69434565, compound

Participants

Reaction Steps

In an autoclave, 10%-palladium/carbon (containing 50% water, 1.0 g) was added to a solution of 2-[1-tetrahydro-2H-pyran-2-yl-5-(tetrahydro-2H-pyran-2-yloxy)-1H-indazol-4-yl]propan-2-ol (1.92 g, 5.33 mmol) in ethanol (26 ml), and the resulting mixture was stirred at 60° C. for 5 hours under a hydrogen atmosphere of 30 atmospheric pressure. The reaction mixture was filtered by the use of Celite and washed with methanol, and then the filtrate was concentrated under reduced pressure to obtain a crude product. The crude product was purified by a silica gel column chromatography (eluent: hexane/ethyl acetate) to obtain 4-isopropyl-1-tetrahydro-2H-pyran-2-yl-5-(tetrahydro-2H-pyran-2-yloxy)-1H-indazole (301 mg, 16%) and 4-isopropyl-1-tetrahydro-2H-pyran-2-yl-1H-indazol-5-ol (586 mg, 42%).

Provenance & Evidence