1,4-Dioxane hydrochloride → HCID 69435281, compound

Participants

Reaction Steps

Under nitrogen, the 4-methyl-5-[(cis-3-morpholin-4-ylcyclohexyl)oxy]-1-tetrahydro-2H-pyran-2-yl-1H-indazole (80 mg, 0.200 mmol) obtained in Example 727 was dissolved in isopropyl alcohol (3 ml), followed by adding thereto 4N-hydrochloric acid/1,4-dioxane (3 ml), and the resulting mixture was stirred at room temperature for 19 hours. The solvent was distilled off under reduced pressure and the resulting concentration residue was purified by a silica gel column chromatography (eluent: acetonitrile/aqueous ammonia=100/0, 100/1, 100/2) to obtain 4-methyl-5-[(cis-3-morpholin-4-ylcyclohexyl)oxy]-1H-indazole (55 mg, yield 87.1%) as a white amorphous substance.

Provenance & Evidence