Ammonium formate → HCID 69435928, compound

Participants

Reaction Steps

Under nitrogen, the N-benzyl-N-methyl-N-[cis-3-[(4-methyl-1H-indazol-5-yl)oxy]cyclohexyl]amine (80 mg, 0.229 mmol) obtained in Example 729 was dissolved in ethanol (4 ml), followed by adding thereto ammonium formate (144 mg, 2.29 mmol) and then 10%-Pd/C (containing 50% water) (20 mg), and the resulting mixture was stirred with heating under reflux for 2 hours. The reaction mixture was cooled to room temperature and the Pd/C was filtered off. Then, the solvent was distilled off under reduced pressure and the resulting concentration residue was purified by a silica gel column chromatography (eluent: acetonitrile/aqueous ammonia=100/0, 100/1, 100/2, 100/4) to obtain N-methyl-N-[cis-3-[(4-methyl-1H-indazol-5-yl)oxy]cyclohexyl]amine (50 mg, yield 84.2%) as a white amorphous substance.

Provenance & Evidence