Hydrazine → (+/-)-3-(2-Pyridyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid

Participants

Reaction Steps

Potassium hydroxide (3.29 g) is dissolved in 250 ml of methanol and 8.85 g of 4-(2-pyridyl)-4-oxo-2-butenoic acid is added. Hydrazine (1.6 g) is then added and the solution is heated at reflux temperature for 5 hours. Solvent is removed in vacuo and the residue is dissolved in 50 ml of water and treated with 3.0 g of acetic acid yielding the title compound.

Provenance & Evidence