Monomethylamine methanol → HCID 69429749, compound

Participants

Reaction Steps

A mixture of the crude product 2-{trans-3-[(4-trifluoromethyl-1H-indazol-5-yl)oxy]cyclohexyl}-1H-isoindole-1,3(2H)-dione (0.324 g) and a 30% methylamine/methanol solution (15 ml) was stirred at 90° C. for 3 hours. The solvent was distilled off and the residue solid was purified by elution by a silica gel column chromatography (chloroform/methanol=20:1→chloroform/methanol/triethylamine=10:1:1) to obtain trans-3-[(4-trifluoromethyl-1H-indazol-5-yl)oxy]cyclohexylamine (70.4 mg, 16%, two steps).

Provenance & Evidence