Methylamine ethanol → HCID 178431634, compound

Participants

Reaction Steps

A mixture of 2-{cis-4-[(4-methyl-1-tetrahydro-2H-pyran-2-yl-1H-indazol-5-yl)oxy]cyclohexyl}-1H-isoindole-1,3(2H)-dione (95.5 mg, 0.208 mmol) and a 30% methylamine-ethanol solution (5.0 ml) was stirred with heating under reflux for 2 hours. The reaction solution was allowed to cool, and then was concentrated under reduced pressure to obtain a crude product. The crude product was purified by a silica gel column chromatography (eluent: chloroform/methanol/28% aqueous ammonia) to obtain cis-4-[(4-methyl-1-tetrahydro-2H-pyran-2-yl-1H-indazol-5-yl)oxy]cyclohexanamine (60.4 mg, 88%).

Provenance & Evidence