Methylamine → HCID 131726322, compound

Participants

Reaction Steps

A 40% methylamine methanolic solution (5 mL) was added to the 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-{cis-3-[(4-methyl-1H-indazol-5-yl)oxy]cyclohexyl}acetamide (70 mg, 0.16 mmol) obtained in Example 825, and the resulting mixture was stirred overnight. The reaction solution was distilled under reduced pressure to remove the solvent and then the residue was purified by a silica gel chromatography. To a solution of the purified residue in 2-propanol was added a hydrochloric acid-diethyl ether solution, and stirred for 30 minutes. After the solvent was distilled off under reduced pressure, the residue was crystallized from 2-propanol-diisopropyl ether-diethyl ether to obtain N˜1˜(identification is required)-{cis-3-[(4-methyl-1H-indazol-5-yl)oxy]cyclohexyl}glycinamide monohydrochloride (39 mg, 79%).

Provenance & Evidence