Tetrahydrofuran → HCID 69432639, compound

Participants

Reaction Steps

The ethyl N-{cis-3-[(4-methyl-1H-indazol-5-yl)oxy]cyclohexyl}glycinate obtained in Example 836 was added to a tetrahydrofuran suspension of lithium aluminum hydride, and the resulting mixture was stirred at room temperature for 3 hours. Water, a 2N-aqueous sodium hydroxide solution and then water were added to the reaction mixture and stirred for 1 hour, followed by filtration using Celite. The filtrate was concentrated and then purified by a preparative thin-layer chromatography (methanol (containing aqueous ammonia)/chloroform=1/10) to obtain 2-({cis-3-[(4-methyl-1H-indazol-5-yl)oxy]cyclohexyl}amino)ethanol (17.6 mg, 40%).

Provenance & Evidence