HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → (R)-1-trichloromethyl-3-methyl-2-butenyl acetoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Phosphoric Acid | HCID 1004 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | (R)-3-methyl-1-trichloromethylbut-2-en-1-yl (S)-3-[N-(1-(1-naphthyl)ethyl)amino]but-2-enoate | HCID 86737543 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (R)-1-trichloromethyl-3-methyl-2-butenyl acetoacetate | HCID 12525204 | — |
Reaction Steps
hydrolyzing the recovered (R)-3-methyl-1-trichloromethylbut-2-en-1-yl (S)-3-[N-(1-(1-naphthyl)ethyl)amino]but-2-enoate in a mixture of tetrahydrofuran and aqueous mineral acid selected from HCl, HBr, HNO3, H3PO4, and H2SO4, about 1-20 equivalents of 0.1 to 4 N aqueous mineral acid being employed for each equivalent of (R)-3-methyl-1-trichloromethylbut-2-en-1-yl (S)-3-[N-(1-(1-naphthyl)ethyl)amino]but-2-enoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04254279 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-caf8b0f49bfd461ea47e9ab68abbf23b |
| Source note | uspto-grants-1981_03 |