Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylenediamine | HCID 3301 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 7-Chloro-1-cyclopropyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 13385163 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 12034150 | HCID 12034150 | 41.8% |
Reaction Steps
To a solution of 7-chloro-1-cyclopropyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid (2.0 g) in 1-methyl-2-pyrrolidinone (20 mL) was added ethylenediamine (2.3 g). The mixture was heated at 130° C. for 10 h. The reaction mixture was cooled and poured into DCM (20 mL). The precipitate obtained was dispersed in MeOH, filtered to give the title compound (910 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07202221B2 |
|---|
| Source dataset | uspto-grants-2007_04 |
|---|
| ORD ID | ord-1268e7fc720241f0826694e059da8ec1 |
|---|
| Source note | uspto-grants-2007_04 |
|---|
