HCID 131726328, compound → HCID 18448972, compound

HRID 1270073Notes

Reaction equation

HRID 1270073 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][C:22]=1[Cl:23])[N:19]([CH:24]1[CH2:26][CH2:25]1)[CH:18]=[C:17]([C:27]([OH:29])=[O:28])[C:16]2=[O:30])=O)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][C:22]=1[Cl:23])[N:19]([CH:24]1[CH2:26][CH2:25]1)[CH:18]=[C:17]([C:27]([OH:29])=[O:28])[C:16]2=[O:30]

Participants

3

Reactant 1

HCID 131726328HCID 131726328, compound

Product 1

HCID 18448972HCID 18448972, compoundYield 133.7%

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

A solution of intermediate 11 (100 mg) in 10% TFA/DCM (1 mL) was stirred at room temperature for 2 h. The solvent was partially evaporated under reduced pressure. For five times the residual was diluted in DCM (2 mL) and concentrated under reduced pressure. Final solvent evaporation afforded the title compound (103 mg).

Workup

  1. customThe solvent was partially evaporated under reduced pressure
  2. additionFor five times the residual was diluted in DCM (2 mL)
  3. concentrationconcentrated under reduced pressure
  4. customFinal solvent evaporation

Sources & evidence

ORD record
ord-659868ebbebd47808b85f08f0f895154
Source dataset
uspto-grants-2007_04
Patent number
US07202221B2

Reaction notes

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