HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 2-(1H-pyrrol-1-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 2-Aminobenzonitrile | HCID 72913 | — |
| Reactant | 2,5-Dimethoxytetrahydrofuran | HCID 79098 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(1H-pyrrol-1-yl)benzonitrile | HCID 707325 | — |
Reaction Steps
A mixture of 2-aminobenzonitrile (0.01 mole), 2,5-dimethoxytetrahydrofuran (0.01 mole) and glacial acetic acid (10 ml) was heated under reflux for 30 minutes (TLC check). The acetic acid and ethyl acetate formed was evaporated off and the residue was purified using flash chromatography on silica gel (eluent: CH2Cl2). The pure fraction was recrystallized from the appropriate solvent (mostly ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07202240B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-ad1fedd2a55b4221817dc89557c2330f |
| Source note | uspto-grants-2007_04 |