4-Chloro-1-naphthol → 4-Chloro-2-[(2-methoxyphenyl)-piperidin-1-yl-methyl]-naphthalen-1-ol

HRID 1270123Notes

Reaction equation

HRID 1270123 reaction equation
[Cl-].[CH3:2][O:3][C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[CH:6]=[N+:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1.[Cl:17][C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:21]([OH:28])=[CH:20][CH:19]=1>>[Cl:17][C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:21]([OH:28])=[C:20]([CH:6]([C:5]2[CH:13]=[CH:14][CH:15]=[CH:16][C:4]=2[O:3][CH3:2])[N:7]2[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12]2)[CH:19]=1

Participants

3

Reactant 2

HCID 117874-Chloro-1-naphtholHCID 179122761-(2-Methoxy-benzylidene)-piperidinium chloride

Product 1

HCID 235008834-Chloro-2-[(2-methoxyphenyl)-piperidin-1-yl-methyl]-naphthalen-1-ol

Procedure

The preparation was carried out in accordance with general synthesis instructions 4 from 1-(2-methoxy-benzylidene)-piperidinium chloride and 4-chloro-1-naphthol.

Sources & evidence

ORD record
ord-b931ba3108dc45a9add83b0665e30798
Source dataset
uspto-grants-2007_04
Patent number
US07202242B2

Reaction notes

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