6-Bromo-2-naphthalenol → 6-Bromo-1-[(2-methoxyphenyl)-piperidin-1-yl-methyl]-naphthalen-2-ol

HRID 1270124Notes

Reaction equation

HRID 1270124 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([OH:12])[CH:6]=[CH:5]2.[Cl-].[CH3:14][O:15][C:16]1[CH:28]=[CH:27][CH:26]=[CH:25][C:17]=1[CH:18]=[N+:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([CH:18]([C:17]1[CH:25]=[CH:26][CH:27]=[CH:28][C:16]=1[O:15][CH3:14])[N:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1)=[C:7]([OH:12])[CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 271446-Bromo-2-naphthalenolHCID 179122761-(2-Methoxy-benzylidene)-piperidinium chloride

Product 1

HCID 235008506-Bromo-1-[(2-methoxyphenyl)-piperidin-1-yl-methyl]-naphthalen-2-ol

Procedure

The preparation was carried out in accordance with general synthesis instructions 4 from 6-bromo-2-naphthol and 1-(2-methoxy-benzylidene)-piperidinium chloride, which had been prepared in accordance with example 32.

Workup

  1. customhad been prepared in accordance with example 32

Sources & evidence

ORD record
ord-a24179cbda12492bafceb765af0c649d
Source dataset
uspto-grants-2007_04
Patent number
US07202242B2

Reaction notes

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