3-Aminopropionitrile → 2-(1,3-benzothiazol-2-yl)ethanamine

HRID 1270141Notes

Reaction equation

HRID 1270141 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]#[N:5].N[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[SH:13]>CCO>[S:13]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:5]=[C:4]1[CH2:3][CH2:2][NH2:1]

Participants

4

Reactant 2

HCID 16473-AminopropionitrileHCID 87132-Aminothiophenol

Product 1

HCID 49625952-(1,3-benzothiazol-2-yl)ethanamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 50 mg of 3-aminopropionitrile and 596 mg of 2-aminothiophenol in EtOH (15 mL) was heated at reflux for six hrs. After cooling the solution to room temperature, the reaction was concentrated and the residue was purified by silica gel chromatography to afford the title compound as a red oil. MS (M+H)+=179.1.

Workup

  1. temperatureat reflux for six hrs
  2. concentrationthe reaction was concentrated
  3. customthe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-46c110edac584c848e7a1fb1729d1fcd
Source dataset
uspto-grants-2007_04
Patent number
US07202245B2

Reaction notes

Loading…