Cyclohexene → HCID 18449239, compound

Participants

Reaction Steps

To a solution of 1.0 g of 4-chloro-8-fluoro-1-methoxy[1,2,4]triazolo[4,3-a]quinoxaline in DMF (12.0 mL) was added 1.36 g of 4-methoxybenzylamine. This solution was stirred at room temperature for 18 hrs. and then diluted with EtOAc and washed with water and saturated lithium chloride. The extracts were dried over sodium sulfate, filtered, and concentrated and the residue was separated by silica gel chromatography to give a yellow solid. This solid was dissolved in MeOH (15 mL) and 160 mg of 10% Pd/C and 0.96 g of cyclohexene were added. This mixture was heated at reflux for 18 hrs., filtered through a pad of diatomaceous earth, and concentrated to provide an off-white solid. MS (M+H)+=340.0.

Provenance & Evidence