Hydrochloric Acid → HCID 69414988, compound

Participants

Reaction Steps

A solution of 152 mg of 4-chloro-8-fluoro-1-methoxy-[1,2,4]triazolo[4,3-a]quinoxaline, 127 mg of glycine ethyl ester hydrochloride, and 602 mg of triethylamine in DMF (4.0 mL) was stirred at room temperature for 41 hrs. The reaction mixture was concentrated, dissolved in 25% IPA/methylene chloride and washed with 50% saturated sodium bicarbonate, and then water. The organic emulsion was collected and concentrated to provide a yellow solid. A solution of this solid in trifluoroethanol (10 mL) was treated with 5 equiv. of 4.0 N HCl in dioxane for 15 min., and the mixture was concentrated. The residue was dissolved in 20% IPA/methylene chloride, and washed with 50% saturated sodium bicarbonate, and then water. The organic emulsion was collected and concentrated to provide a yellow solid which was triturated. The resulting off-white solid was collected, dried, washed with ether and dried to provide the title compound. MS (M+H)+=306.0.

Provenance & Evidence