Acetonitrile → HCID 18449242, compound

Participants

Reaction Steps

A solution of 300 mg of 4-chloro-8-fluoro-1-methoxy-[1,2,4]triazolo[4,3-a]quinoxaline, 221 mg of tert-butyl-N-(piperazine)carbamate, and 360 mg of triethylamine in acetonitrile (4.0 mL) was stirred at room temperature. After 16 hrs., the solvent was removed, and the residue was separated by silica gel chromatography to give 280 mg of a yellow foam. The foam was dissolved in a 1:1.5 mixture of 48% HBr/AcOH, and the mixture was heated to reflux for 2 hrs. The reaction mixture was concentrated to give 97 mg of a yellow solid. MS (M−H)−=287.1.

Provenance & Evidence