Sodium Carbonate → HCID 18449238, compound

HRID 1270152Notes

Reaction equation

HRID 1270152 reaction equation
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[C:7]([N:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)[C:8]3[N:9]2[C:12](=[O:15])[NH:13][N:14]=3)=[CH:4][CH:3]=1.Cl[C:23]1[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][N:24]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)CCC>[F:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[C:7]([N:16]3[CH2:17][CH2:18][N:19]([C:23]4[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][N:24]=4)[CH2:20][CH2:21]3)[C:8]3[N:9]2[C:12](=[O:15])[NH:13][N:14]=3)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 923422-Chloro-5-(trifluoromethyl)pyridineHCID 18449242HCID 18449242, compound

Product 1

HCID 18449238HCID 18449238, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A solution of 40 mg of 8-fluoro-4-piperazin-1-yl-[1,2,4]triazolo[4,3-a]quinoxalin-1-one, 48 mg of 2-chloro-5-trifluoromethylpyridine, and 47 mg of sodium carbonate in n-butanol (1 mL) was heated to reflux for 24 hrs. The reaction mixture was cooled to room temperature, filtered through a plug of diatomaceous earth, and evaporated to dryness. The residue was separated by silica gel chromatography to provide a white solid. MS (M+H)+=434.0.

Workup

  1. temperatureto reflux for 24 hrs
  2. filtrationfiltered through a plug of diatomaceous earth
  3. customevaporated to dryness
  4. customThe residue was separated by silica gel chromatography
  5. customto provide a white solid

Sources & evidence

ORD record
ord-3a3780d684284810a524a107ee869f02
Source dataset
uspto-grants-2007_04
Patent number
US07202245B2

Reaction notes

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