Tetramethyl orthocarbonate → HCID 86594420, compound

HRID 1270159Notes

Reaction equation

HRID 1270159 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[C:10]([NH:15][NH2:16])[C:9]([Cl:17])=[N:8]2)=[O:4].[CH3:18][O:19][C:20](OC)(OC)OC>>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]1[C:18]([O:19][CH3:20])=[N:16][N:15]=[C:10]1[C:9]([Cl:17])=[N:8]2)=[O:4]

Participants

3

Reactant 2

HCID 74613Tetramethyl orthocarbonateHCID 57470539HCID 57470539, compound

Product 1

HCID 86594420HCID 86594420, compound

Conditions

Temperature
23 °C

Procedure

A solution of 3-chloro-2-hydrazino-quinoxaline-6-carboxylic acid methyl ester (890 mg) in tetramethylorthocarbonate (10 mL) was heated at 100° C. for three hrs. After cooling to 23° C., the precipitated solid was isolated by filtration and rinsed with EtOAc, providing 4-chloro-1-methoxy-[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid methyl ester as an orange solid. MS (M+H)+=293.2.

Workup

  1. customthe precipitated solid was isolated by filtration
  2. washrinsed with EtOAc

Sources & evidence

ORD record
ord-91c3bcb51eb7440ab355e3602cdb044d
Source dataset
uspto-grants-2007_04
Patent number
US07202245B2

Reaction notes

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