HCID 18449243, compound → HCID 18449207, compound

HRID 1270167Notes

Reaction equation

HRID 1270167 reaction equation
O[CH2:2][C:3]1[CH:12]=[C:11]2[C:6]([N:7]=[C:8]([NH:17][CH:18]([CH3:20])[CH3:19])[C:9]3[N:10]2[C:13](=[O:16])[NH:14][N:15]=3)=[CH:5][CH:4]=1.[H][H]>CCO.[Pd]>[CH:18]([NH:17][C:8]1[C:9]2[N:10]([C:13](=[O:16])[NH:14][N:15]=2)[C:11]2[C:6]([N:7]=1)=[CH:5][CH:4]=[C:3]([CH3:2])[CH:12]=2)([CH3:20])[CH3:19]

Participants

5

Reactant 2

HCID 18449243HCID 18449243, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18449207HCID 18449207, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 8-hydroxymethyl-4-isopropylamino-2H-[1,2,4]triazolo[4,3-a]quinoxalin-1-one (20 mg) in EtOH (15 mL) was treated 10% Pd/C (10 mg), and the mixture was agitated under 45 psi hydrogen atmosphere for 68 hrs. The reaction mixture was filtered through diatomaceous earth, the filtrate concentrated, and the residue purified by silica gel chromatography to provide the title compound as a solid. MS (M+H)+=258.0.

Workup

  1. filtrationThe reaction mixture was filtered through diatomaceous earth
  2. concentrationthe filtrate concentrated
  3. customthe residue purified by silica gel chromatography

Sources & evidence

ORD record
ord-6eeba0f51812498f9e3e908452c97232
Source dataset
uspto-grants-2007_04
Patent number
US07202245B2

Reaction notes

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